J. Matthew Huyck

8½ Pleasant Street, Hanover, NH 03755 ✩ (617) 905-7917 ✩ cv@fgtech.com

Areas of Expertise

Professional Experience

2/2021 – present
Substitute Teacher, Lyme School District - SAU 76, Lyme, NH

Substitute teaching as needed for elementary and middle school. Subjects taught include math, science, design lab, Spanish, and social studies.

9/2015 – 5/2020
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Integrative Genomics Laboratory, GreeneLab

Part-time Software Developer with Casey Greene's lab designing and building open source tools that allow biologists to generate new hypotheses about their data. Ongoing collaboration with the Hogan Lab to refine the ADAGE web server (see adage.greenelab.com).

5/2015 – 1/2018
Geisel School of Medicine at Dartmouth, Lebanon, NH Department of Molecular & Systems Biology

Part-time Software Developer with Casey Greene's lab designing and building open source tools that allow biologists to generate new hypotheses about their data. Ongoing collaboration with the Hogan Lab to refine the ADAGE web server (see adage.greenelab.com).

9/2011 – 4/2014
Geisel School of Medicine at Dartmouth, Lebanon, NH New Hampshire Birth Cohort Study

Part-time Data Manager assisting with post-collection data management needs of the project. Responsibilities included database migration, importing lab results, maintaining and expanding data extraction procedures and consolidating and reconciling data from diverse sources to support the needs of data analysts and collaborators.

9/2007 – 8/2011
Boston University, Boston, MA Biomolecular Systems Laboratory, DeLisi Lab

Research Assistant working on new methods for creating, analyzing and visualizing biological networks to gain a deeper understanding of human diseases and how they relate to one another.

6/2006 – 9/2008
Harvard Medical School, Boston, MA Center for Biomedical Informatics, Computational Biology Initiative

Computational Biology Programmer responsible for creating novel tools to extract knowledge from biomedical literature. Developing methods for building, analyzing and visualizing networks of interacting proteins associated with various diseases, focusing on autism. Responsibilities include evaluating methods and software for an automated text retrieval system using natural language processing, designing and implementing a software architecture to support integration of all system components, and creating and enhancing components using Java and database development expertise.

1/2003 – 5/2006
Boston University, Boston, MA College of Medicine, Genetics Program

Database Specialist responsible for performing statistical analysis and creating and maintaining data collection and extraction procedures for MIRAGE (an international, multi-center study into the genetic and environmental causes of Alzheimer Disease) and associated studies.

1/2003 – 6/2010
SAS and Biostatistics Tutor

Provided SAS and biostatistics tutoring to area biomedical and public health graduate students.

3/2002 – 6/2010
Brigham and Women’s Hospital/Harvard Medical School, Boston, MA Departments of Pathology and of Obstetrics, Gynecology, and Reproductive Biology

Sole technical consultant for the Center for Uterine Fibroids and the “Finding Genes for Fibroids” study, a large international study to identify susceptibility genes for uterine fibroids. I streamlined, enhanced and linked study databases maintained in Microsoft Access and Excel containing all DNA, contact information and data collection records from over 1500 study participants. I also provided support for the Center’s web site and assisted with SAS programming.

Volunteer Experience

Fall, 2022
Coach, Lyme School Robotics Team, Lyme, NH

Provided structure and guidance for the student-led FIRST LEGO League robotics team. This was Lyme's first time fielding a team and the group advanced to the state competition.

Winter, 2021
Ski Coach, Lyme Recreation Ski Program, Lyme, NH

Taught a group of beginner and intermediate students from Lyme School how to navigate the Nordic ski trails around Lyme. I have also supported this program as a parent volunteer in other years.

5/2020 – present
Senior Advisor, Vermont RETAIN, Hanover, NH

Provide advice and guidance on all manner of technology-related questions as a volunteer advisor for leadership of the Vermont RETAIN project.

Education

9/2007 – 8/2011
Boston University, College of Engineering and College of Arts and Sciences Graduate work in Bioinformatics
Summer, 2003
Boston University, School of Public Health Department of Biostatistics Applied Linkage Analysis (BS859)
Spring, 2003
Boston University, School of Public Health Department of Epidemiology Epidemiology (EB711) Department of Biostatistics Biostatistics (EB703)
8/1991 – 5/1995
B.S., Cornell University, College of Engineering School of Applied and Engineering Physics (A&EP)

Coursework included advanced physics, advanced mathematics, engineering, laboratory instrumentation, computer hardware interfacing, and computer science.

Software Development Skills

Bibliography

Software

Publications

  1. Tan J, Huyck M, Hu D, Zelaya RA, Hogan DA, Greene CS. ADAGE signature analysis: differential expression analysis with data-defined gene sets. BMC Bioinformatics 18:512, 2017.
  2. Hu Z, Hung JH, Wang Y, Chang YC, Huang CL, Huyck M, DeLisi C. VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology. Nucleic Acids Research 37(suppl 2):W115-W121, 2009.
  3. Wall DP, Esteban FJ, DeLuca TF, Huyck M, Monaghan T, Velez de Mendizabal N, Goñí J, Kohane IS. Comparative analysis of neurological disorders focuses genome-wide search for autism genes. Genomics. 93(2):120-129, 2009.
  4. Wellner B, Huyck M, Mardis S, Aberdeen J, Morgan A, Peshkin L, Yeh A, Hitzeman J and Hirschman L. Rapidly Retargetable Approaches to De-identification in Medical Records. Journal of the American Medical Informatics Association. 14(5):564-573, 2007.
  5. Akomolafe A, Lunetta KL, Erlich PM, Cupples LA, Baldwin CT, Huyck M, Green RC, Farrer LA; MIRAGE Study Group. Genetic association between endothelial nitric oxide synthase and Alzheimer disease. Clinical Genetics. 70(1):49-56, 2006.
  6. Erlich PM, Lunetta KL, Cupples LA, Huyck M, Green RC, Baldwin CT, Farrer LA; MIRAGE Study Group. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Human Molecular Genetics. 15(1):77-85, 2006.
  7. Yip AG, Green RC, Huyck M, Cupples LA, Farrer LA; MIRAGE Study Group. Nonsteroidal anti-inflammatory drug use and Alzheimer’s disease risk: the MIRAGE Study. BMC Geriatrics. 5(1):2, 2005.
  8. Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 429(6987):75-9, 2004.